小鼠黑色素瘤生长刺激活性基因（Mgsa）具有多态性，并且与5号染色体上的W、斑驳、臀部白色和隐性斑点基因座同线。

Mouse melanoma growth stimulatory activity gene (Mgsa) is polymorphic and syntenic with the W, patch, rumpwhite, and recessive spotting loci on chromosome 5.

作者信息

Sakaguchi A Y, Lalley P A, Choudhury G G, Martinez L, Han E S, Killary A M, Naylor S L, Wang L M

机构信息

Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.

出版信息

Genomics. 1989 Oct;5(3):629-32. doi: 10.1016/0888-7543(89)90033-5.

DOI:10.1016/0888-7543(89)90033-5

PMID:2575589

Abstract

Melanoma growth stimulatory activity (Mgsa) is a polypeptide growth factor originally detected in culture medium of the human malignant melanoma cell line Hs294T and may have an autocrine role in neoplastic growth. Mgsa is a member of the small inducible gene (SIG) family and shares homology with beta-thromboglobulin and platelet factor 4. Mgsa was localized to chromosome 5 using a cDNA probe for mouse Mgsa and somatic cell hybrids and is thus syntenic with Kit (W), Ph, Rw, and rs loci. The results eliminate Mgsa as the product of the Steel locus on chromosome 10, but raise the possibility that Mgsa might be synonymous with a chromosome 5 locus affecting skin pigmentation.

摘要

黑色素瘤生长刺激活性（Mgsa）是一种最初在人恶性黑色素瘤细胞系Hs294T的培养基中检测到的多肽生长因子，可能在肿瘤生长中具有自分泌作用。Mgsa是小诱导基因（SIG）家族的成员，与β-血小板球蛋白和血小板因子4具有同源性。使用小鼠Mgsa的cDNA探针和体细胞杂种将Mgsa定位到5号染色体，因此它与Kit（W）、Ph、Rw和rs位点同线。这些结果排除了Mgsa是10号染色体上Steel位点的产物，但增加了Mgsa可能与影响皮肤色素沉着的5号染色体位点同义的可能性。