Grammatico P, Roccella M, Catricalà C, Roccella F, Bucher S, Mordenti C, Amantea A, Di Rosa C, Del Porto G
Cattedra di Genetica Medica, Università La Sapienza, Rome, Italy.
World J Surg. 1995 May-Jun;19(3):350-1. doi: 10.1007/BF00299156.
The GRO1 oncogene (melanoma growth-stimulating activity alpha) has been localized in region 4q21. The involvement of this chromosomal region in clonal aberrations found in primary melanoma cell cultures could have an important role in the etiology and pathogenesis of this tumor. We characterized three primary cell cultures obtained from different patients, each of which showed clonal chromosomal aberrations involving the 4q21 region.
GRO1癌基因（黑色素瘤生长刺激活性α）已定位在4q21区域。该染色体区域参与原发性黑色素瘤细胞培养中发现的克隆性畸变，可能在该肿瘤的病因学和发病机制中起重要作用。我们对从不同患者获得的三种原代细胞培养物进行了特征分析，每种培养物均显示涉及4q21区域的克隆性染色体畸变。
