Elliot Alexandra, Jangard Mattias, Marklund Linda, Håkansson Niclas, Dickman Paul, Hammarstedt-Nordenvall Lalle, Stjärne Pär
Rhinology. 2015 Mar;53(1):75-80. doi: 10.4193/Rhino14.070.
Sinonasal malignancies (SNM) are rare and the prognosis is generally poor. Recently, a change in incidence for SNM has been reported. In this study, we investigated population-based trends for SNM in Sweden.
We identified 3,221 patients from the Swedish National Cancer Registry diagnosed with primary malignancies arising from the nasal cavity, paranasal sinuses, or both, during the period 1960 through 2010. Incidence, gender and age, anatomical sites and relative survival were investigated.
The incidence for SNM decreased except for sinonasal malignant melanoma (SNMM) and adenoid cystic cancer (even though a very small group) during the study period. More than 50 % of the malignancies involved the nasal cavity. The five-year relative survival was highest for adenoid cystic cancer followed by adenocarcinoma. SNMM and undifferentiated carcinoma had the poorest prognosis.
We found that the incidence for SNM has decreased during the study period 1960 through 2010, except for SNMM that has increased.
鼻窦恶性肿瘤（SNM）较为罕见，预后通常较差。最近，有报道称SNM的发病率出现了变化。在本研究中，我们调查了瑞典基于人群的SNM发病趋势。
我们从瑞典国家癌症登记处识别出3221例患者，这些患者在1960年至2010年期间被诊断患有源自鼻腔、鼻窦或两者的原发性恶性肿瘤。我们对发病率、性别和年龄、解剖部位以及相对生存率进行了调查。
在研究期间，除鼻窦恶性黑色素瘤（SNMM）和腺样囊性癌（尽管病例数很少）外，SNM的发病率有所下降。超过50%的恶性肿瘤累及鼻腔。腺样囊性癌的五年相对生存率最高，其次是腺癌。SNMM和未分化癌的预后最差。
我们发现，在1960年至2010年的研究期间，SNM的发病率有所下降，但SNMM的发病率有所上升。
