Yakovlev A A, Gulyaeva N V
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, 117485, Russia.
Biochemistry (Mosc). 2015 Feb;80(2):163-71. doi: 10.1134/S0006297915020030.
Preconditioning (PC) is one of the most effective strategies to reduce the severity of cell damage, in particular of nervous tissue cells. Although PC mechanisms are studied insufficiently, it is clear that proteases are involved in them, but their role has yet been not studied in detail. In this work, some mechanisms of a potential recruiting of proteases in PC are considered. Our attention is mainly focused on the protease families of caspases and cathepsins and on protease receptors. We present evidence that just these proteins are involved in the PC of brain cells. A hypothesis is proposed that secreted cathepsin B is involved in the realization of PC through activation of PAR2 receptor.
预处理（PC）是减轻细胞损伤严重程度，尤其是神经组织细胞损伤严重程度的最有效策略之一。尽管对PC机制的研究尚不充分，但很明显蛋白酶参与其中，不过它们的作用尚未得到详细研究。在这项工作中，我们考虑了蛋白酶在PC中潜在募集的一些机制。我们的注意力主要集中在半胱天冬酶和组织蛋白酶的蛋白酶家族以及蛋白酶受体上。我们提供的证据表明，正是这些蛋白质参与了脑细胞的PC过程。我们提出了一个假设，即分泌的组织蛋白酶B通过激活PAR2受体参与PC的实现。
