[弥漫性泛细支气管炎患者血清唾液酸化Lewis X-i（SLX）的临床评估]

[Clinical evaluation of serum sialyl Lewis X-i (SLX) in diffuse panbronchiolitis].

作者信息

Noguchi M, Nakatani T, Chohnabayashi N, Nakamori Y, Nakata K, Matsushita H, Tanimoto H

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1989 Mar;27(3):317-25.

Abstract

Clinical comparison of SLX with other tumor-associated antigens such as CA19-9, CA125, and CEA, was made in benign respiratory diseases including diffuse panbronchiolitis (DPB), bronchiectasis (BE), bronchial asthma (BA), and pulmonary emphysema (PE). Sensitivities of each marker (greater than 38.0 U/ml) on DPB were 79.4% in SLX, 68.0% in CA19-1, 46.7% in CA125, and 35.7% in CEA. Serum levels of SLX in DPB and BE were significantly higher than those in BA and PE. There seemed to be no relationship between serum levels of SLX and CRP, ESR, and the volume of sputum. Immunohistochemical studies showed positive staining on the surface of respiratory bronchioles and alveolar walls in DPB and these findings were not observed in normal lung tissues. We consider that the high value of serum levels of SLX in DPB can be explained by these findings.

摘要

在包括弥漫性泛细支气管炎（DPB）、支气管扩张（BE）、支气管哮喘（BA）和肺气肿（PE）在内的良性呼吸系统疾病中，对SLX与其他肿瘤相关抗原（如CA19-9、CA125和CEA）进行了临床比较。在DPB中，每种标志物（大于38.0 U/ml）的敏感性分别为：SLX为79.4%，CA19-1为68.0%，CA125为46.7%，CEA为35.7%。DPB和BE患者的血清SLX水平显著高于BA和PE患者。血清SLX水平与CRP、ESR及痰液量之间似乎没有关系。免疫组织化学研究显示，DPB患者的呼吸性细支气管和肺泡壁表面呈阳性染色，而正常肺组织中未观察到这些结果。我们认为，这些结果可以解释DPB患者血清SLX水平较高的原因。