Lin Maria H, Wood Jamie R, Mittelman Steven D, Freyer David R
*Center for Endocrinology, Diabetes and Metabolism †Diabetes & Obesity Program §LIFE Cancer Survivorship & Transition Program/Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles ‡Keck School of Medicine, University of Southern California, Los Angeles, CA.
J Pediatr Hematol Oncol. 2015 May;37(4):e253-7. doi: 10.1097/MPH.0000000000000320.
Survivors of acute lymphoblastic leukemia have increased risk for long-term cardiovascular complications. Early identification of cardiovascular risk factors (CVRF) may allow for effective interventions. In this retrospective cohort study of 194 patients at Children's Hospital Los Angeles, we investigated CVRF screening practices in an established childhood cancer survivorship program relative to both the Children's Oncology Group (COG) Long-Term Follow-Up Guidelines and American Academy of Pediatrics (AAP) recommendations. CVRF screening practices met COG but not the more stringent AAP recommendations, particularly in areas of dyslipidemia and diabetes screening. Implications of our findings are discussed.
急性淋巴细胞白血病幸存者长期发生心血管并发症的风险增加。早期识别心血管危险因素(CVRF)可能有助于采取有效的干预措施。在这项对洛杉矶儿童医院194例患者的回顾性队列研究中,我们相对于儿童肿瘤学组(COG)长期随访指南和美国儿科学会(AAP)的建议,调查了一个成熟的儿童癌症幸存者项目中的CVRF筛查实践。CVRF筛查实践符合COG的要求,但不符合更为严格的AAP建议,尤其是在血脂异常和糖尿病筛查方面。我们讨论了研究结果的意义。