Department of Pediatrics, Turku University Hospital, Turku, Finland.
Pediatr Blood Cancer. 2012 Jul 15;59(1):155-60. doi: 10.1002/pbc.24049. Epub 2011 Dec 19.
Long-term survivors of childhood acute lymphoblastic leukemia (ALL) have increased risk of cardiovascular disease (CVD). The prevalence of insulin resistance and other cardiometabolic risk factors is increased in ALL survivors, and insufficient physical activity (PA) and low cardiopulmonary fitness are common. The purpose of this study was to evaluate the effects of a simple, inexpensive home-based exercise program on cardiometabolic risk factors and fitness in long-term ALL survivors.
Seventeen 16- to 30-year-old survivors of childhood ALL (age at diagnosis ≤16 years) were recruited to a 16-week home-based exercise program. Peak oxygen uptake (VO(2 peak)), muscle strength, and metabolic risk factors were studied before and after the exercise program.
Fasting plasma insulin (P = 0.01), HOMA-IR (homeostasis model assessment, insulin resistance) (P = 0.002), waist circumference (P = 0.003), waist-to-hip ratio (P = 0.002), fat percent (P = 0.04), and supine diastolic blood pressure (P = 0.03) decreased during the program, while weight and body mass index remained unchanged. VO(2 peak) and maximal work load (W/kg) improved by 5% (P = 0.01 and P = 0.02, respectively) during the exercise program. The results of the Sit-Up test, Back extensor test, and Full Squatting test improved as well (P = 0.01, P = 0.002, and P = 0.0004, respectively).
A simple home-based exercise program was effective in improving cardiometabolic risk factor status and fitness in young adult survivors of childhood ALL. Simple exercise programs should be recommended to this population with increased risk of CVD to improve metabolic risk factor status and fitness.
儿童期急性淋巴细胞白血病（ALL）的长期幸存者患心血管疾病（CVD）的风险增加。ALL 幸存者中胰岛素抵抗和其他心血管代谢危险因素的患病率增加，体力活动（PA）不足和心肺功能差很常见。本研究的目的是评估一种简单、廉价的家庭运动方案对长期 ALL 幸存者的心血管代谢危险因素和健康的影响。
招募了 17 名 16 至 30 岁的儿童期 ALL 幸存者（诊断时年龄≤16 岁）参与一项为期 16 周的家庭运动方案。在运动方案前后研究了峰值摄氧量（VO2peak）、肌肉力量和代谢危险因素。
空腹血浆胰岛素（P = 0.01）、HOMA-IR（胰岛素抵抗的稳态模型评估）（P = 0.002）、腰围（P = 0.003）、腰臀比（P = 0.002）、体脂百分比（P = 0.04）和仰卧舒张压（P = 0.03）在方案期间下降，而体重和体重指数保持不变。VO2peak 和最大工作负荷（W/kg）在运动方案期间分别提高了 5%（P = 0.01 和 P = 0.02）。仰卧起坐测试、背伸肌测试和深蹲测试的结果也有所改善（P = 0.01、P = 0.002 和 P = 0.0004）。
一项简单的家庭运动方案可有效改善儿童期 ALL 成年幸存者的心血管代谢危险因素状况和健康状况。应向这一 CVD 风险增加的人群推荐简单的运动方案，以改善代谢危险因素状况和健康。
