双侧视网膜母细胞瘤的极晚期复发

Very late relapse of bilateral retinoblastoma.

作者信息

Choi Jung Yoon, Kang Hyoung Jin, Lee Ji Won, Ju Hee Young, Hong Che Ry, Kim Hyery, Yu Young Suk, Park Sung-Hye, Cheon Jung-Eun, Park Kyung Duk, Shin Hee Young

机构信息

Departments of *Pediatrics §Ophthalmology ∥Pathology ¶Radiology, Seoul National University College of Medicine †Cancer Research Institute, Seoul National University ‡Department of Pediatrics, Seoul National University Boramae Medical Center, Seoul, Korea.

出版信息

J Pediatr Hematol Oncol. 2015 May;37(4):e264-7. doi: 10.1097/MPH.0000000000000310.

DOI:10.1097/MPH.0000000000000310

PMID:25757022

Abstract

Retinoblastoma usually recurs within the first few years after treatment completion. We report a rare case of very late relapse in a 6-month-old girl who was diagnosed with bilateral retinoblastoma. The patient achieved first remission after treatment with neoadjuvant chemotherapy, enucleation of the right eye, local laser therapy of the left eye, and adjuvant chemotherapy. Extraocular relapse with multiple metastases occurred 13 years and 8 months after treatment. The patient is currently in second complete remission after receiving high-dose chemotherapy and autologous stem cell transplantation. In conclusion, long-term follow-up is needed for early detection of recurrent retinoblastoma.

摘要

视网膜母细胞瘤通常在治疗结束后的头几年内复发。我们报告了一例罕见的极晚期复发病例，患者为一名6个月大的双侧视网膜母细胞瘤女孩。该患者在接受新辅助化疗、右眼摘除、左眼局部激光治疗及辅助化疗后首次缓解。治疗13年零8个月后出现眼外复发并伴有多处转移。该患者在接受大剂量化疗和自体干细胞移植后目前处于第二次完全缓解状态。总之，需要进行长期随访以早期发现复发性视网膜母细胞瘤。