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豚鼠颈上神经节中含强啡肽的立毛运动神经元。

Dynorphin-containing pilomotor neurons in the superior cervical ganglion of guinea pigs.

作者信息

Gibbins I L

机构信息

Department of Anatomy and Histology, School of Medicine, Flinders University of South Australia, Bedford Park.

出版信息

Neurosci Lett. 1989 Dec 15;107(1-3):45-50. doi: 10.1016/0304-3940(89)90788-x.

DOI:10.1016/0304-3940(89)90788-x
PMID:2575729
Abstract

Retrograde axonal tracing and double-labelling immunofluorescence have been combined to determine the neuropeptide content of identified pilomotor neurons in the superior cervical ganglion of guinea pigs. These neurons lacked immunoreactivity to neuropeptide Y (NPY) but they generally contained low levels of immunoreactivity to prodynorphin-derived peptides, including dynorphin A(1-8), dynorphin A(1-17), and alpha-neo-endorphin. Thus pilomotor neurons are neurochemically distinct from superior cervical ganglion cells which contain immunoreactivity to NPY and prodynorphin-derived peptides and which innervate the iris and most of the vasculature in the head of guinea pigs. They are also distinct from sympathetic secretomotor neurons which lack both NPY and prodynorphin-derived peptides.

摘要

逆行轴突追踪和双标免疫荧光技术相结合,以确定豚鼠颈上神经节中已鉴定的立毛运动神经元的神经肽含量。这些神经元对神经肽Y(NPY)缺乏免疫反应性,但它们通常对前强啡肽衍生肽具有低水平的免疫反应性,包括强啡肽A(1-8)、强啡肽A(1-17)和α-新内啡肽。因此,立毛运动神经元在神经化学上与颈上神经节细胞不同,颈上神经节细胞对NPY和前强啡肽衍生肽具有免疫反应性,并支配豚鼠头部的虹膜和大部分血管。它们也不同于既缺乏NPY又缺乏前强啡肽衍生肽的交感分泌运动神经元。

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