Hu Tao, Zhu Hua-Xu, Guo Li-Wei, Pan Lin-Mei, Li Bo, Shi Fei-Yan, Lu Jin
Yao Xue Xue Bao. 2014 Nov;49(11):1607-13.
For effective inhalable dry-powder drug delivery, tetrandrine-PLGA (polylactic-co-glycolic acid) nanocomposite particles have been developed to overcome the disadvantages of nanoparticles and microparticles. The primary nanoparticles were prepared by using premix membrane emulsification method. To prepare second particles, they were spray dried. The final particles were characterized by scanning electron microscopy (SEM), dry laser particle size analysis, high performance liquid chromatography (HPLC), X-ray diffraction (XRD), differential scanning calorimetry (DSC), infrared analysis (IR) and confocal laser scanning microscope (CLSM). The average size of the primary particles was (337.5 ± 6.2) nm, while that second particles was (3.675 ± 0.16) μm which can be decomposed into primary nanoparticles in water. And the second particles were solid sphere-like with the drug dispersed as armorphous form in them. It is a reference for components delivery to lung in a new form.
为实现有效的可吸入干粉药物递送，已研发出粉防己碱-聚乳酸-羟基乙酸共聚物（PLGA）纳米复合颗粒，以克服纳米颗粒和微粒的缺点。通过预混膜乳化法制备初级纳米颗粒。为制备二级颗粒，将它们进行喷雾干燥。通过扫描电子显微镜（SEM）、干式激光粒度分析、高效液相色谱（HPLC）、X射线衍射（XRD）、差示扫描量热法（DSC）、红外分析（IR）和共聚焦激光扫描显微镜（CLSM）对最终颗粒进行表征。初级颗粒的平均尺寸为（337.5±6.2）nm，而二级颗粒的平均尺寸为（3.675±0.16）μm，其在水中可分解为初级纳米颗粒。并且二级颗粒呈实心球状，药物以无定形形式分散在其中。这为以新形式向肺部递送成分提供了参考。
