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[先天性孤立肾婴儿因输尿管梗阻性结石合并诺如病毒胃肠炎导致急性肾衰竭]

[Acute renal failure due to obstructive ureteral stone associated with norovirus gastroenteritis in an infant with congenital solitary kidney].

作者信息

Kato Taiki, Hamano Atsushi, Kawamura Hideki

出版信息

Nihon Hinyokika Gakkai Zasshi. 2014 Oct;105(4):224-8. doi: 10.5980/jpnjurol.105.224.

Abstract

We report a 35 month-old boy with acute renal failure caused by an obstructive ureteral stone associated with norovirus gastroenteritis. He visited his family physician because of fever, abdominal pain and vomiting. He was diagnosed as acute gastroenteritis. The symptoms relieved once, but abdominal pain and vomiting recurred two days after the visit and the volume of urine decreased. He was diagnosed as norovirus gastoenteritis and acute renal failure which was unresponsive to fluid replacement. Ultrasound study of the abdomen showed a solitary kidney with mild hydronephrosis. He was then admitted to our hospital. He was finally diagnosed as acute postrenal failure due to obstructive ureteral stone with left solitary kidney by abdominal computer tomography (CT). We performed transurethral catheterization immediately. The creatinine and blood urea nitrogen returned to normal level in 2 days. The CT performed on the 28th day post operation showed disappearance of the stone after uric alkalization. Recently, some cases of postrenal failure due to bilateral obstructive ureteral stones, mainly ammonium acid urate stones, associated with viral gastroenteritis were reported. As clinical features, they are common in boys three years or younger after an episode of rotavirus gastroenteritis with high uric acid concentration. By far, the most common cause of acute renal failure in patients with severe gastroenteritis is prerenal failure resulting from hypovolemia. But postrenal cause due to bilateral obstructive stones should be taken in a consideration.

摘要

我们报告一名35个月大的男孩,因输尿管梗阻性结石合并诺如病毒胃肠炎导致急性肾衰竭。他因发热、腹痛和呕吐就诊于家庭医生,被诊断为急性胃肠炎。症状曾一度缓解,但就诊两天后腹痛和呕吐复发,尿量减少。他被诊断为诺如病毒胃肠炎和急性肾衰竭,补液治疗无效。腹部超声检查显示单肾伴轻度肾积水。随后他被收入我院。最终经腹部计算机断层扫描(CT)诊断为左单肾输尿管梗阻性结石所致急性肾后性肾衰竭。我们立即进行了经尿道插管。肌酐和血尿素氮在2天内恢复正常水平。术后第28天的CT显示尿酸碱化后结石消失。最近,有报道称一些双侧输尿管梗阻性结石(主要是尿酸铵结石)合并病毒性胃肠炎导致肾后性肾衰竭的病例。作为临床特征,这些病例常见于3岁或以下的男孩,在轮状病毒胃肠炎发作后尿酸浓度升高。到目前为止,重症胃肠炎患者急性肾衰竭最常见的原因是血容量不足导致的肾前性肾衰竭。但应考虑双侧梗阻性结石导致的肾后性原因。

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