Schenk Susan, Bradbury Sarah
Victoria University of Wellington, School of Psychology, P.O. Box 600, Wellington, New Zealand.
Victoria University of Wellington, School of Psychology, P.O. Box 600, Wellington, New Zealand.
Pharmacol Biochem Behav. 2015 May;132:103-107. doi: 10.1016/j.pbb.2015.03.001. Epub 2015 Mar 8.
Effects of MDMA exposure on MDMA-produced hyperactivity are dependent on the exposure regimen; high-dose exposure produced tolerance whereas repeated, intermittent exposure produced sensitised responses. In the present study we measured the impact of MDMA self-administration on MDMA-produced hyperactivity. Rats self-administered a total of 165mg/kg MDMA during daily 2h sessions. Control rats self-administered vehicle solution and were matched to the MDMA self-administering rats so that they had the same number of daily exposures to handling and the chamber. Behavioural measures were collected either 5 or 14days following the last MDMA self-administration session and 14days following the last vehicle self-administration session. Following a 30min habituation period, rats received an injection of MDMA (10.0mg/kg, IP) and various measures of MDMA-produced hyperactivity were measured. Speed of forward locomotion and rearing, behaviours that are often attributed to dopaminergic mechanisms, increased following both abstinence periods. These data are consistent with a persistent sensitisation of dopamine substrates as a result of MDMA self-administration.
摇头丸暴露对摇头丸所致多动的影响取决于暴露方案；高剂量暴露会产生耐受性，而反复、间歇性暴露则会产生敏感化反应。在本研究中，我们测量了摇头丸自我给药对摇头丸所致多动的影响。大鼠在每天2小时的实验时段内共自我给药165mg/kg摇头丸。对照大鼠自我给药溶剂，并与摇头丸自我给药大鼠相匹配，以使它们每天接受处理和进入实验箱的次数相同。行为测量在最后一次摇头丸自我给药实验后的5天或14天以及最后一次溶剂自我给药实验后的14天进行。经过30分钟的适应期后，大鼠接受一次摇头丸注射（10.0mg/kg，腹腔注射），并测量各种摇头丸所致多动的指标。向前运动速度和竖毛行为通常归因于多巴胺能机制，在两个戒断期后均增加。这些数据与摇头丸自我给药导致多巴胺底物持续敏感化一致。
