Licari Melissa K, Billington Jac, Reid Siobhan L, Wann John P, Elliott Catherine M, Winsor Anne M, Robins Erin, Thornton Ashleigh L, Jones Randall, Bynevelt Michael
School of Sport Science, Exercise and Health, The University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia,
Exp Brain Res. 2015 Jun;233(6):1703-10. doi: 10.1007/s00221-015-4243-7. Epub 2015 Mar 11.
This study examined brain activation in children with developmental coordination disorder (DCD) to reveal areas that may contribute to poor movement execution and/or abundant motor overflow. Using functional magnetic resonance imaging, 13 boys with DCD (mean age = 9.6 years ±0.8) and 13 typically developing controls (mean age = 9.3 years ±0.6) were scanned performing two tasks (finger sequencing and hand clenching) with their dominant hand, while a four-finger motion sensor recorded contralateral motor overflow on their non-dominant hand. Despite displaying increased motor overflow on both functional tasks during scanning, there were no obvious activation deficits in the DCD group to explain the abundant motor overflow seen. However, children with DCD were found to display decreased activation in the left superior frontal gyrus on the finger-sequencing task, an area which plays an integral role in executive and spatially oriented processing. Decreased activation was also seen in the left inferior frontal gyrus, an area typically active during the observation and imitation of hand movements. Finally, increased activation in the right postcentral gyrus was seen in children with DCD, which may reflect increased reliance on somatosensory information during the execution of complex fine motor tasks.
本研究检测了发育性协调障碍（DCD）患儿的大脑激活情况，以揭示可能导致动作执行不佳和/或大量运动溢出的区域。利用功能磁共振成像技术，对13名患有DCD的男孩（平均年龄=9.6岁±0.8）和13名发育正常的对照儿童（平均年龄=9.3岁±0.6）进行扫描，他们用优势手执行两项任务（手指排序和握拳），同时一个四指运动传感器记录其非优势手的对侧运动溢出情况。尽管在扫描过程中两项功能任务中均显示出运动溢出增加，但DCD组中没有明显的激活缺陷来解释所观察到的大量运动溢出。然而，发现患有DCD的儿童在手指排序任务中左侧额上回的激活减少，该区域在执行和空间定向处理中起着不可或缺的作用。在左侧额下回也观察到激活减少，该区域在观察和模仿手部动作时通常是活跃的。最后，患有DCD的儿童右侧中央后回的激活增加，这可能反映了在执行复杂精细运动任务时对体感信息的依赖增加。
