一种简便的串联迈克尔加成/O-环化/消除反应路线合成新型色烯并[3,2-c]吡啶。
A facile tandem Michael addition/O-cyclization/elimination route to novel chromeno[3,2-c]pyridines.
作者信息
Sumesh Remani Vasudevan, Malathi Akilan, Ranjith Kumar Raju
机构信息
Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, 625 021, Tamil Nadu, India.
出版信息
Mol Divers. 2015 May;19(2):233-49. doi: 10.1007/s11030-015-9576-4. Epub 2015 Mar 11.
PMID:25758540
Abstract
A facile and efficient synthesis of a library of novel chromeno[3,2-c]pyridines has been achieved from the reaction of various 3,5-((E)-arylidene)-1-alkylpiperidin-4-ones and cyclic 1,3-diketones. The reaction presumably occurred via tandem Michael addition-intramolecular O-cyclization-elimination sequence in a single operation.
摘要
通过各种3,5-（（E）-亚芳基）-1-烷基哌啶-4-酮与环状1,3-二酮的反应，实现了一系列新型色烯并[3,2-c]吡啶的简便高效合成。该反应可能通过串联迈克尔加成-分子内O-环化-消除序列在一步操作中发生。
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