Theplib Arisa, Phupong Vorapong
a Department of Obstertrics and Gynecology, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.
J Matern Fetal Neonatal Med. 2016 Mar;29(5):841-4. doi: 10.3109/14767058.2015.1021671. Epub 2015 Mar 17.
To determine terbutaline success rate in postponing preterm labor for 48 h and to identify factors associated with its efficacy, side effects, maternal and neonatal outcomes.
A retrospective study analyzing data from pregnant women suffering from preterm labor who had received terbutaline for inhibition of labor from January 2007 to December 2013.
A total of 385 cases were analyzed; there were 321 cases (83.4%) delivered ≥48 h and 64 cases (16.6%) delivered before 48 h. The factors that affect the success rate of terbutaline administration in singleton pregnancy were cervical dilatation (ORs 0.37; 95% CI 0.18-0.79) and cervical effacement (ORs 0.36; 95% CI 0.17-0.75). The most common side effect of terbutaline was tachycardia (95.1%), but there were no serious cardiovascular events and maternal death. Mean neonatal birth weight was 2.294.3 ± 638.4 g. Neonatal complications included respiratory distress syndrome (RDS) 16.2%, intraventricular hemorrhage (IVH) 1.4%, necrotizing enterocolitis (NEC) 0.7%, sepsis 5.3%, and neonatal death 0.9%.
The success rate of terbutaline in treatment of preterm labor was high whereas side effects were tolerable. Neonatal outcome was good. The factors that significantly affect the success rate of terbutaline administration in singleton pregnancy were cervical dilatation and cervical effacement. Thus, terbutaline can be used safely for short-term treatment of preterm labor.
确定特布他林将早产推迟48小时的成功率，并确定与其疗效、副作用、母婴结局相关的因素。
一项回顾性研究，分析2007年1月至2013年12月期间接受特布他林抑制宫缩的早产孕妇的数据。
共分析了385例病例；321例（83.4%）分娩时间≥48小时，64例（16.6%）在48小时前分娩。单胎妊娠中影响特布他林给药成功率的因素为宫颈扩张（比值比0.37；95%可信区间0.18 - 0.79）和宫颈消退（比值比0.36；95%可信区间0.17 - 0.75）。特布他林最常见的副作用是心动过速（95.1%），但未发生严重心血管事件和孕产妇死亡。新生儿平均出生体重为2294.3±638.4克。新生儿并发症包括呼吸窘迫综合征（RDS）16.2%、脑室内出血（IVH）1.4%、坏死性小肠结肠炎（NEC）0.7%、败血症5.3%和新生儿死亡0.9%。
特布他林治疗早产的成功率较高，副作用可耐受。新生儿结局良好。单胎妊娠中显著影响特布他林给药成功率的因素是宫颈扩张和宫颈消退。因此，特布他林可安全用于早产的短期治疗。
