Anandan Rangasamy, Chatterjee Niladri Sekhar, Sivakumar Ramalingam, Mathew Suseela, Asha Kurukkan Kunnath, Ganesan Balaraman
Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), Cochin, 682029, Kerala, India,
Biol Trace Elem Res. 2015 Sep;167(1):103-9. doi: 10.1007/s12011-015-0289-4. Epub 2015 Mar 11.
Myocardial infarction is one of the major public concerns in both developed and developing countries. Recently, there is growing interest in potential healthcare applications of marine natural products in the field of cardiovascular research. In the present study, we have examined the membrane-stabilizing potential of marine mucopolysaccharide-chitosan in modulating the aberrations of thiol-dependent membrane-bound ATPases activities, mineral status, and cardiac diagnostic markers in isoproterenol-induced myocardial infarction condition in rats. Dietary intake of chitosan significantly (p < 0.05) counteracted the isoproterenol-induced lipid peroxidation and maintained the levels of thiol contents and cardiac biomarkers at concentrations analogous to that of normal controls in the rat myocardium. Chitosan administration also significantly mitigated isoproterenol-induced aberrations in the membrane-bound ATPase activities in the heart tissue and preserved the myocardial mineral status in serum and heart tissue of experimental rats at near normal value. The results of the present study have indicated that the salubrious effect of dietary chitosan supplementation in attenuating the experimentally induced myocardial infarction condition is probably ascribable to its antioxidant defense and membrane-stabilizing properties.
心肌梗死是发达国家和发展中国家主要的公共关注问题之一。最近，海洋天然产物在心血管研究领域的潜在医疗应用受到越来越多的关注。在本研究中，我们检测了海洋粘多糖-壳聚糖在调节异丙肾上腺素诱导的大鼠心肌梗死状态下硫醇依赖性膜结合ATP酶活性、矿物质状态和心脏诊断标志物异常方面的膜稳定潜力。壳聚糖的饮食摄入显著（p < 0.05）抵消了异丙肾上腺素诱导的脂质过氧化，并在大鼠心肌中维持了硫醇含量和心脏生物标志物的水平，其浓度与正常对照组相似。壳聚糖给药还显著减轻了异丙肾上腺素诱导的心脏组织中膜结合ATP酶活性异常，并使实验大鼠血清和心脏组织中的心肌矿物质状态保持在接近正常的值。本研究结果表明，饮食补充壳聚糖对减轻实验性诱导的心肌梗死状态的有益作用可能归因于其抗氧化防御和膜稳定特性。
