铜催化手性N-叔丁基亚磺酰亚胺的不对称烯丙基化反应：具有近乎完美非对映选择性的双重立体控制
Copper-catalyzed asymmetric allylation of chiral N-tert-butanesulfinyl imines: dual stereocontrol with nearly perfect diastereoselectivity.
作者信息
Zhao Yi-Shuang, Liu Qiang, Tian Ping, Tao Jing-Chao, Lin Guo-Qiang
机构信息
College of Chemistry and Molecular Engineering, Zhengzhou University, 75 Daxue Road, Zhengzhou, Henan 450052, China.
出版信息
Org Biomol Chem. 2015 Apr 14;13(14):4174-8. doi: 10.1039/c5ob00322a. Epub 2015 Mar 11.
PMID:25758913
Abstract
Copper-catalyzed asymmetric allylation of chiral N-tert-butanesulfinyl imines has been described. Dual stereocontrol, through the combination of a chiral auxiliary and a chiral copper complex, has played an important role in achieving the nearly perfect diastereoselectivities (all dr > 99 : 1), especially for ketimine substrates.
摘要
已报道了铜催化的手性N-叔丁基亚磺酰亚胺的不对称烯丙基化反应。通过手性助剂和手性铜配合物的组合实现的双重立体控制，在实现近乎完美的非对映选择性（所有dr>99:1）方面发挥了重要作用，尤其是对于酮亚胺底物。
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