Basal activities of adenylate and guanylate cyclase in lymphocytes and platelets of alcoholics.

Basal activities of adenylate cyclase and guanylate cyclase were determined in lymphocytes and platelets of alcoholics with different severity of alcoholic withdrawal syndrome. Compared to controls, significant changes were found in the basal activities of adenylate and guanylate cyclase in all groups of patients. Adenylate cyclase activity in lymphocytes has a positive correlation to the severity of the clinical states. Although we found increased guanylate cyclase activities in lymphocytes and decreased activities in platelets compared to controls, similar values of activities were obtained in all groups of alcoholics independently of their clinical state.