夏季活跃的地松鼠（侧纹黄鼠）肾素释放对体外前列腺素刺激的反应。

Renin release responses to in vitro prostaglandin challenge in the summer-active ground squirrel, Spermophilus lateralis.

Lopez G A, Lopez N, Brazal S, Natividad M

Department of Biology, California State University, Los Angeles 90032.

Comp Biochem Physiol A Comp Physiol. 1989;94(4):575-81. doi: 10.1016/0300-9629(89)90596-3.

Abstract

Using a renal cortical slice preparation from the summer-active ground squirrel, Spermophilus lateralis, resting renin release (RR) and tissue cyclic AMP content (TcAMPC) levels were found to be significantly higher and lower, respectively, than those previously reported for its hibernating counterpart. 2. At a 10(-5) M dose, PGE2 but not PGE1, PGF2-alpha or PGA1, significantly stimulated RR in the summer-active ground squirrel (SAGS). 3. Addition of agents which normally increase TcAMPC significantly potentiated the effect of PGE1, while preventing that of PGE2, on RR and TcAMPC. 4. Opposite TcAMPC changes may mediate the in vitro RR responses to PGE1 and PGE2 administration in the SAGS.

摘要

使用来自夏季活跃的地松鼠（侧纹黄鼠）的肾皮质切片标本，发现其静息肾素释放（RR）和组织环磷酸腺苷含量（TcAMPC）水平分别显著高于和低于此前报道的冬眠期同类动物。2. 在10^(-5) M剂量下，前列腺素E2（PGE2）而非前列腺素E1（PGE1）、前列腺素F2α（PGF2-α）或前列腺素A1（PGA1）能显著刺激夏季活跃地松鼠（SAGS）的RR。3. 添加通常会增加TcAMPC的试剂，可显著增强PGE1对RR和TcAMPC的作用，同时抑制PGE2的作用。4. TcAMPC的相反变化可能介导了SAGS中体外RR对PGE1和PGE2给药的反应。