Red blood cell (RBC) count, RBC size, hematocrit, cell and blood hemoglobin concentrations and plasma total solid concentration were measured in 16 lowland (from near sea level up to 2700 m) and 18 highland (3200 up to close to 4500 m) adult toads (Bufo spinulosus). 2. Lowland toads showed higher hematocrit values than highland toads, but their blood hemoglobin concentration and plasma solid concentration were not significantly different. 3. Highland toads had smaller RBC size, higher corpuscular hemoglobin concentration, a trend toward larger RBC count and a considerably smaller body size. These features may contribute to their successful life at high altitude.