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[脯氨酰-亮氨酰-甘氨酸（MIF-1）和1-甲基-4-苯基-1,2,3,6-四氢吡啶对纹状体多巴胺水平的影响]

[The effect of prolyl-leucyl-glycine (MIF-1) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on dopamine levels of the striatum].

作者信息

Sheng J G

出版信息

Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1989 Aug;22(4):213-5, 253.

PMID:2575971
Abstract

We report that large dose MPTP-treated mice bring about a reduction in the levels of DA, 5-HT and their metabolites in the striatum. In the mice pretreated with PLG, although the striatal DA level was also reduced, mean DA and 5-HT levels were significantly higher than in mice given MPTP alone. It is concluded that PLG can prevent, at least partially, the neurotoxic effect of MPTP. We assume that the mechanism of action of PLG may directly or indirectly reduce MPTP-induced dopaminergic neurotoxicity in the nigrostriatal system or reduce the affinity of MPP+ to melanin in DA cells.

摘要

我们报告，大剂量MPTP处理的小鼠导致纹状体中多巴胺（DA）、5-羟色胺（5-HT）及其代谢产物水平降低。在用聚乳酸-乙醇酸共聚物（PLG）预处理的小鼠中，虽然纹状体DA水平也降低，但平均DA和5-HT水平显著高于仅给予MPTP的小鼠。得出的结论是，PLG可至少部分预防MPTP的神经毒性作用。我们推测，PLG的作用机制可能直接或间接降低MPTP在黑质纹状体系统中诱导的多巴胺能神经毒性，或降低1-甲基-4-苯基吡啶离子（MPP+）对DA细胞中黑色素的亲和力。

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1
[The effect of prolyl-leucyl-glycine (MIF-1) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on dopamine levels of the striatum].[脯氨酰-亮氨酰-甘氨酸（MIF-1）和1-甲基-4-苯基-1,2,3,6-四氢吡啶对纹状体多巴胺水平的影响]
Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1989 Aug;22(4):213-5, 253.
2
Partial protection from the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by Pro-Leu-Gly-NH2(PLG; MIF-1).
Life Sci. 1987 May 18;40(20):2007-10. doi: 10.1016/0024-3205(87)90291-8.
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Dehydroepiandrosterone (DHEA) such as 17beta-estradiol prevents MPTP-induced dopamine depletion in mice.脱氢表雄酮（DHEA）如17β-雌二醇可预防小鼠中MPTP诱导的多巴胺耗竭。
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Neonatal exposure to paraquat or MPTP induces permanent changes in striatum dopamine and behavior in adult mice.
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l-dopa-induced reversal in striatal glutamate following partial depletion of nigrostriatal dopamine with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.用1-甲基-4-苯基-1,2,3,6-四氢吡啶部分耗尽黑质纹状体多巴胺后左旋多巴诱导的纹状体谷氨酸逆转。
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In brown Norway rats, MPP+ is accumulated in the nigrostriatal dopaminergic terminals but it is not neurotoxic: a model of natural resistance to MPTP toxicity.在棕色挪威大鼠中，MPP+在黑质纹状体多巴胺能终末中蓄积，但它没有神经毒性：一种对MPTP毒性天然抵抗的模型。
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