Lenoble Quentin, Bubbico Giovanna, Szaffarczyk Sébastien, Pasquier Florence, Boucart Muriel
Laboratoire de Neurosciences Fonctionnelles et Pathologies, Université Lille Nord de France, CNRS, Lille, France.
Centre Mémoire, CHU, Université Lille Nord de France, Lille, France.
Dement Geriatr Cogn Dis Extra. 2015 Jan 16;5(1):1-12. doi: 10.1159/000366054. eCollection 2015 Jan-Apr.
We investigated the performance in scene categorization of patients with Alzheimer's disease (AD) using a saccadic choice task.
24 patients with mild AD, 28 age-matched controls and 26 young people participated in the study. The participants were presented pairs of coloured photographs and were asked to make a saccadic eye movement to the picture corresponding to the target scene (natural vs. urban, indoor vs. outdoor).
The patients' performance did not differ from chance for natural scenes. Differences between young and older controls and patients with AD were found in accuracy but not saccadic latency.
The results are interpreted in terms of cerebral reorganization in the prefrontal and temporo-occipital cortex of patients with AD, but also in terms of impaired processing of visual global properties of scenes.
我们使用扫视选择任务研究了阿尔茨海默病（AD）患者在场景分类方面的表现。
24名轻度AD患者、28名年龄匹配的对照者和26名年轻人参与了该研究。向参与者展示成对的彩色照片，并要求他们进行扫视眼动，看向与目标场景（自然场景与城市场景、室内场景与室外场景）相对应的图片。
患者在自然场景方面的表现与随机水平无异。在准确性方面发现了年轻对照组与老年对照组以及AD患者之间的差异，但在扫视潜伏期方面未发现差异。
这些结果可从AD患者前额叶和颞枕叶皮质的脑重组角度来解释，也可从场景视觉全局属性处理受损的角度来解释。
