患者对抗甲状腺药物引起的粒细胞缺乏症的认识。
Patient knowledge of antithyroid drug-induced agranulocytosis.
机构信息
Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, Harrogate, UK.
British Thyroid Foundation, Harrogate, UK.
出版信息
Eur Thyroid J. 2014 Dec;3(4):245-51. doi: 10.1159/000367990. Epub 2014 Oct 15.
BACKGROUND
Agranulocytosis is a serious side effect of antithyroid drugs.
OBJECTIVE
To ascertain the knowledge of patients and review the quality of information available on the internet.
METHODS
A questionnaire survey was performed for patients receiving antithyroid drugs. Patients attending endocrine clinics who were receiving antithyroid drug treatment (group A, n = 33) were interviewed. A further national cohort of patients (group B, n = 100) treated with antithyroid drugs, participated in an online survey.
RESULTS
60.9% of responders were not aware of the common symptoms of agranulocytosis. 18.6% had never received any information about side effects. Of the 108 patients who recalled receiving information, 30% rated the quality as 'poor' or 'not good at all'. Structured interviews of group A patients revealed that almost half (45.5%, 15/33) had experienced symptoms that could be indicative of agranulocytosis, but only 53.3% (8/15) had a blood count checked. A review of 20 selected patient information internet sites revealed a significant variation in advice given to patients.
CONCLUSIONS
Inadequate knowledge about agranulocytosis among patients receiving antithyroid drug treatment is common. The available information on the internet is variable and inconsistent.
背景
粒细胞缺乏症是抗甲状腺药物的一种严重副作用。
目的
确定患者的知识水平，并评估互联网上可用信息的质量。
方法
对接受抗甲状腺药物治疗的患者进行问卷调查。访谈了在内分泌科就诊、正在接受抗甲状腺药物治疗的患者（A 组，n = 33）。此外，还对接受抗甲状腺药物治疗的全国性队列患者（B 组，n = 100）进行了在线调查。
结果
60.9%的应答者不知道粒细胞缺乏症的常见症状。18.6%从未接受过任何关于副作用的信息。在回忆收到信息的 108 名患者中，30%将质量评为“差”或“非常差”。对 A 组患者的结构化访谈显示，近一半（45.5%，15/33）患者出现了可能表明粒细胞缺乏症的症状，但只有 53.3%（8/15）进行了血常规检查。对 20 个选定的患者信息网站进行审查后发现，网站向患者提供的建议存在显著差异。
结论
接受抗甲状腺药物治疗的患者对粒细胞缺乏症的认识不足很常见。互联网上提供的信息是可变且不一致的。
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