Henrion D, Eglème C, Criscione L, Wood J M
Department of Cardiovascular Research, Ciba-Geigy, Ltd., Basel, Switzerland.
J Pharm Pharmacol. 1989 Nov;41(11):766-9. doi: 10.1111/j.2042-7158.1989.tb06362.x.
The influence of changing baseline blood pressure by various means, both related or unrelated to the renin-angiotensin system, on the pressor responses to spinal cord stimulation has been examined in the pithed rat. Mean arterial pressure and neurogenic vasoconstriction were higher in pithed rats with intact kidneys (2-kidney rats) than in nephrectomized pithed rats. Increasing blood pressure by infusion of vasopressin increased the pressor response to nerve stimulation in both 2-kidney and nephrectomized pithed rats. Decreasing blood pressure produced by administration of enalaprilat or hydralazine in 2-kidney pithed rats or by administration of hydralazine in nephrectomized pithed rats, decreased the pressor responses to nerve stimulation. Our results showed a positive correlation between the mean arterial blood pressure and the response to nerve stimulation in pithed rats. Therefore, we conclude that the pithed rat is an animal model which should be used with caution to study the interaction between the sympathetic nervous system and drugs which change baseline blood pressure.
通过各种与肾素 - 血管紧张素系统相关或不相关的方法改变基础血压，对脊髓刺激所致升压反应的影响，已在脊髓横断大鼠中进行了研究。有完整肾脏的脊髓横断大鼠（双肾大鼠）的平均动脉压和神经源性血管收缩高于肾切除的脊髓横断大鼠。通过输注血管加压素升高血压，可增加双肾和肾切除脊髓横断大鼠对神经刺激的升压反应。在双肾脊髓横断大鼠中给予依那普利拉或肼屈嗪，或在肾切除脊髓横断大鼠中给予肼屈嗪降低血压，会降低对神经刺激的升压反应。我们的结果表明，脊髓横断大鼠的平均动脉血压与对神经刺激的反应之间呈正相关。因此，我们得出结论，脊髓横断大鼠是一种动物模型，在研究交感神经系统与改变基础血压的药物之间的相互作用时应谨慎使用。
