日本人群中咖啡摄入量与全因死亡率及特定病因死亡率的关联：基于日本公共卫生中心的前瞻性研究

Association of coffee intake with total and cause-specific mortality in a Japanese population: the Japan Public Health Center-based Prospective Study.

作者信息

Saito Eiko, Inoue Manami, Sawada Norie, Shimazu Taichi, Yamaji Taiki, Iwasaki Motoki, Sasazuki Shizuka, Noda Mitsuhiko, Iso Hiroyasu, Tsugane Shoichiro

机构信息

From the Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan (ES, M Inoue, NS, TS, TY, M Iwasaki, SS, and ST); the Graduate School of Medicine, The University of Tokyo, Tokyo, Japan (ES and M Inoue); the Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan (MN); and Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka-fu, Japan (HI).

出版信息

Am J Clin Nutr. 2015 May;101(5):1029-37. doi: 10.3945/ajcn.114.104273. Epub 2015 Mar 11.

DOI:10.3945/ajcn.114.104273

PMID:25762807

Abstract

BACKGROUND

Despite the rising consumption of coffee worldwide, few prospective cohort studies assessed the association of coffee intake with mortality including total and major causes of death.

OBJECTIVE

We aimed to investigate the association between habitual coffee drinking and mortality from all causes, cancer, heart disease, cerebrovascular disease, respiratory disease, injuries, and other causes of death in a large-scale, population-based cohort study in Japan.

DESIGN

We studied 90,914 Japanese persons aged between 40 and 69 y without a history of cancer, cerebrovascular disease, or ischemic heart disease at the time of the baseline study. Subjects were followed up for an average of 18.7 y, during which 12,874 total deaths were reported. The association between coffee intake and risk of total and cause-specific mortality was assessed by using a Cox proportional hazards regression model with adjustment for potential confounders.

RESULTS

We showed an inverse association between coffee intake and total mortality in both men and women. HRs (95% CIs) for total death in subjects who consumed coffee compared with those who never drank coffee were 0.91 (0.86-0.95) for <1 cup/d, 0.85 (0.81-0.90) for 1-2 cups/d, 0.76 (0.70-0.83) for 3-4 cups/d, and 0.85 (0.75-0.98) for >5 cups/d (P-trend < 0.001). Coffee was inversely associated with mortality from heart disease, cerebrovascular disease, and respiratory disease.

CONCLUSION

With this prospective study, we suggest that the habitual intake of coffee is associated with lower risk of total mortality and 3 leading causes of death in Japan.

摘要

背景

尽管全球咖啡消费量不断上升，但很少有前瞻性队列研究评估咖啡摄入量与包括全因死亡率和主要死因在内的死亡率之间的关联。

目的

在日本一项大规模的基于人群的队列研究中，我们旨在调查习惯性咖啡饮用与全因、癌症、心脏病、脑血管疾病、呼吸系统疾病、损伤及其他死因导致的死亡率之间的关联。

设计

我们研究了90914名年龄在40至69岁之间、在基线研究时无癌症、脑血管疾病或缺血性心脏病病史的日本人。对受试者平均随访18.7年，在此期间共报告了12874例死亡。使用Cox比例风险回归模型评估咖啡摄入量与全因和特定病因死亡率风险之间的关联，并对潜在混杂因素进行调整。

结果

我们发现男性和女性的咖啡摄入量与全因死亡率之间均呈负相关。与从不喝咖啡的人相比，每天饮用咖啡的受试者全因死亡的HR（95%CI）分别为：每天饮用咖啡少于1杯者为0.91（0.86 - 0.95），每天饮用1 - 2杯者为0.85（0.81 - 0.90），每天饮用3 - 4杯者为0.76（0.70 - 0.83），每天饮用超过5杯者为0.85（0.75 - 0.98）（P趋势<0.001）。咖啡与心脏病、脑血管疾病和呼吸系统疾病导致的死亡率呈负相关。