来自海洋来源的抗癌天然产物麦考醇的全合成及结构修正。
Total synthesis and structural revision of mycalol, an anticancer natural product from the marine source.
作者信息
Seetharamsingh B, Rajamohanan P R, Reddy D Srinivasa
机构信息
†Division of Organic Chemistry and ‡Central NMR Facility, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.
出版信息
Org Lett. 2015 Apr 3;17(7):1652-5. doi: 10.1021/acs.orglett.5b00345. Epub 2015 Mar 12.
PMID:25763453
Abstract
The total synthesis of an anticancer (anaplastic thyroid) natural lipid mycalol has been accomplished for the first time. Synthesis of originally proposed structure necessitated the revision of structure in which the position of acetate group moved from C20 to C19 and a change in stereochemistry of the glycerol unit.
摘要
首次完成了一种抗癌（间变性甲状腺）天然脂质麦考醇的全合成。最初提出的结构的合成需要对结构进行修正，其中乙酰基的位置从C20移至C19，甘油单元的立体化学也发生了变化。
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