van Barneveld T, Seidell J C, Traag N, Hautvast J G
Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands.
Eur J Clin Nutr. 1989 Dec;43(12):809-18.
In this study we describe the associations between indicators of fatness, fat distribution, and alcohol consumption (gamma-glutamyl transferase) with serum lipids and blood pressure in a random selected group (n = 69) of 38-year old men. Waist circumference, subscapular skinfold and body mass index all had similar positive associations with total cholesterol, triglycerides and diastolic blood pressure. Gamma-glutamyl transferase levels were associated with indicators of fatness and fat distribution (waist circumference, waist/hip ratio, body mass index, and subscapular skinfold) and serum lipids (total cholesterol, LDL-cholesterol, triglycerides). Gamma-glutamyl transferase and body mass index both made independent contributions to the explanation of the waist/hip ratio. In multiple regression analysis, gamma-glutamyl transferase levels were (after adjustment for waist/hip ratio and body mass index) associated with serum lipids (total cholesterol, LDL-cholesterol, and triglycerides), but not with HDL-cholesterol and blood pressure. Body mass index only showed an independent relation to triglyceride levels, whereas the waist/hip ratio was only associated with diastolic blood pressure in multiple regression. It is concluded that gamma-glutamyl transferase levels are a potentially important indicator of abdominal fat distribution and unfavourable lipoprotein profiles.
在本研究中，我们描述了在一组随机选取的69名38岁男性中，肥胖指标、脂肪分布指标以及饮酒量（γ-谷氨酰转移酶）与血脂和血压之间的关联。腰围、肩胛下皮褶厚度和体重指数与总胆固醇、甘油三酯及舒张压均呈现相似的正相关。γ-谷氨酰转移酶水平与肥胖指标和脂肪分布指标（腰围、腰臀比、体重指数及肩胛下皮褶厚度）以及血脂（总胆固醇、低密度脂蛋白胆固醇、甘油三酯）相关。γ-谷氨酰转移酶和体重指数对腰臀比的解释均有独立贡献。在多元回归分析中，γ-谷氨酰转移酶水平（在调整腰臀比和体重指数后）与血脂（总胆固醇、低密度脂蛋白胆固醇和甘油三酯）相关，但与高密度脂蛋白胆固醇和血压无关。体重指数仅与甘油三酯水平呈现独立关系，而在多元回归中腰臀比仅与舒张压相关。研究得出结论，γ-谷氨酰转移酶水平是腹部脂肪分布和不良脂蛋白谱的一个潜在重要指标。
