Andarawis-Puri Nelly, Flatow Evan L, Soslowsky Louis J
Leni and Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1188, New York, New York, 10029.
J Orthop Res. 2015 Jun;33(6):780-4. doi: 10.1002/jor.22869. Epub 2015 Apr 24.
Tendinopathy and tendon rupture are common and disabling musculoskeletal conditions. Despite the prevalence of these injuries, a limited number of investigators are conducting fundamental, basic science studies focused on understanding processes governing tendinopathies and tendon healing. Development of effective therapeutics is hindered by the lack of fundamental guiding data on the biology of tendon development, signal transduction, mechanotransduction, and basic mechanisms underlying tendon pathogenesis and healing. To propel much needed progress, the New Frontiers in Tendon Research Conference, co-sponsored by NIAMS/NIH, the Orthopaedic Research Society, and the Icahn School of Medicine at Mount Sinai, was held to promote exchange of ideas between tendon researchers and basic science experts from outside the tendon field. Discussed research areas that are underdeveloped and represent major hurdles to the progress of the field will be presented in this review. To address some of these outstanding questions, conference discussions and breakout sessions focused on six topic areas (Cell Biology and Mechanics, Functional Extracellular Matrix, Development, Mechano-biology, Scarless Healing, and Mechanisms of Injury and Repair), which are reviewed in this special issue and briefly presented in this review. Review articles in this special issue summarize the progress in the field and identify essential new research directions.
肌腱病和肌腱断裂是常见的、会导致功能障碍的肌肉骨骼疾病。尽管这些损伤很普遍，但进行基础科学研究以深入了解肌腱病和肌腱愈合过程的研究人员数量有限。由于缺乏关于肌腱发育生物学、信号转导、机械转导以及肌腱发病机制和愈合的基本机制的基础指导数据，有效治疗方法的开发受到阻碍。为推动急需的进展，由美国国立关节炎、肌肉骨骼和皮肤疾病研究所/美国国立卫生研究院、骨科研究协会以及西奈山伊坎医学院共同主办的肌腱研究新前沿会议召开，以促进肌腱研究人员与肌腱领域以外的基础科学专家之间的思想交流。本综述将介绍讨论的尚未充分发展且代表该领域进展主要障碍的研究领域。为解决其中一些突出问题，会议讨论和分组会议聚焦于六个主题领域（细胞生物学与力学、功能性细胞外基质、发育、机械生物学、无瘢痕愈合以及损伤与修复机制），本特刊对这些领域进行了综述，本综述将简要介绍。本特刊中的综述文章总结了该领域的进展并确定了重要的新研究方向。
