Lipman Kelsey, Wang Chenchao, Ting Kang, Soo Chia, Zheng Zhong
David Geffen School of Medicine.
Division of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA, USA.
Drug Des Devel Ther. 2018 Mar 20;12:591-603. doi: 10.2147/DDDT.S154660. eCollection 2018.
Both acute and chronic tendinopathy result in high morbidity, requiring management that is often lengthy and expensive. However, limited and conflicting scientific evidence surrounding current management options has presented a challenge when trying to identify the best treatment for tendinopathy. As a result of shortcomings of current treatments, response to available therapies is often poor, resulting in frustration in both patients and physicians. Due to a lack of understanding of basic tendon-cell biology, further scientific investigation is needed in the field for the development of biological solutions. Optimization of new delivery systems and therapies that spatially and temporally mimic normal tendon physiology hold promise for clinical application. This review focuses on the clinical importance of tendinopathy, the structure of healthy tendons, tendon injury, and healing, and a discussion of current approaches for treatment that highlight the need for the development of new nonsurgical interventions.
急性和慢性肌腱病都会导致高发病率，需要进行往往漫长且昂贵的治疗。然而，围绕当前治疗方案的科学证据有限且相互矛盾，这在试图确定肌腱病的最佳治疗方法时构成了挑战。由于当前治疗方法存在缺陷，对现有疗法的反应往往不佳，这让患者和医生都感到沮丧。由于对肌腱细胞生物学的基本原理缺乏了解，该领域需要进一步开展科学研究以开发生物学解决方案。优化能够在空间和时间上模拟正常肌腱生理机能的新给药系统和疗法有望应用于临床。本综述重点关注肌腱病的临床重要性、健康肌腱的结构、肌腱损伤与愈合，并讨论当前的治疗方法，突出了开发新的非手术干预措施的必要性。
