哌仑西平、阿托品、间苯三酚和六甲铵对节前慢性去神经支配的人腮腺的唾液分泌作用。

Salivatory effects induced by pirenzepine, atropine, metacine and hexamethonium in preganglionar chronically denervated human parotid gland.

作者信息

Levin S L, Kiselman I M

机构信息

Clinic for Nervous Diseases and Neurosurgery of Medical Pediatric College, Leningrad, USSR.

出版信息

J Pharm Pharmacol. 1989 Dec;41(12):868-71. doi: 10.1111/j.2042-7158.1989.tb06391.x.

DOI:10.1111/j.2042-7158.1989.tb06391.x

PMID:2576453

Abstract

Both classical (atropine) and non-traditional (pirenzepine, metacine) antagonists of the muscarinic cholinoreceptors induce, rather than block, an intense and prolonged salivary response in chronically denervated human parotid glands and thus are capable of discriminating between neuronal and aneuronal receptors. Hexamethonium (benzohexonium) a ganglion-blocking agent (0.4 mL, 2.5%) completely inhibits this paradoxical salivation to atropine, benzilylcholine (metacine) and pirenzepine in the chronic preganglionically denervated human parotid gland. The authors discuss the essence of the revealed paradoxical phenomena.

摘要

毒蕈碱型胆碱能受体的经典拮抗剂（阿托品）和非传统拮抗剂（哌仑西平、美他辛）在慢性去神经支配的人腮腺中引发而非阻断强烈且持久的唾液分泌反应，因此能够区分神经元受体和非神经元受体。神经节阻断剂六甲铵（苄基六甲铵）（0.4 mL，2.5%）可完全抑制慢性节前去神经支配的人腮腺中对阿托品、苯甲酰胆碱（美他辛）和哌仑西平的这种反常唾液分泌。作者讨论了所揭示的反常现象的本质。