安昌灵可减轻左旋乳清酸诱导的帕金森病模型中的病变。
Anchanling reduces pathology in a lactacystin- induced Parkinson's disease model.
机构信息
Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China.
Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China ; Shenzhen Institute of Gerontology, Second Clinical Medical College, Jinan University, Shenzhen 518020, Guangdong Province, China.
出版信息
Neural Regen Res. 2012 Jan 25;7(3):165-70. doi: 10.3969/j.issn.1673-5374.2012.03.001.
A rat model of Parkinson's disease was induced by injecting lactacystin stereotaxically into the left mesencephalic ventral tegmental area and substantia nigra pars compacta. After rats were intragastrically perfused with Anchanling, a Chinese medicine, mainly composed of magnolol, for 5 weeks, when compared with Parkinson's disease model rats, tyrosine hydroxylase expression was increased, α-synuclein and ubiquitin expression was decreased, substantia nigra cell apoptosis was reduced, and apomorphine-induced rotational behavior was improved. Results suggested that Anchanling can ameliorate Parkinson's disease pathology possibly by enhancing degradation activity of the ubiquitin-proteasome system.
采用立体定位向左侧中脑腹侧被盖区和黑质致密部注射乳清酸酶的方法诱导帕金森病大鼠模型，给予安颤灵灌胃 5 周后，与帕金森病模型大鼠比较，酪氨酸羟化酶表达增加，α-突触核蛋白和泛素表达减少，黑质细胞凋亡减少，阿扑吗啡诱导的旋转行为改善。结果提示，安颤灵可能通过增强泛素-蛋白酶体系统的降解活性改善帕金森病的病理变化。
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