生长激素释放因子和生长抑素对大鼠GH1细胞7B2分泌的影响。
Effect of GRF and somatostatin on 7B2 secretion by rat GH1 cells.
作者信息
Iguchi H, Natori S, Nawata H
机构信息
Department of Biochemistry, National Kyushu Cancer Center, Fukuoka, Japan.
出版信息
Endocrinol Jpn. 1989 Dec;36(6):787-93. doi: 10.1507/endocrj1954.36.787.
PMID:2576751
Abstract
A novel pituitary protein "7B2" was secreted by GH1 cells. The secretion of 7B2 was increased in the presence of human GRF in a dose-responsive manner. In contrast, a somatostatin analog, SMS 201-995, revealed the inhibitory effects on the basal- and GRF-induced secretion of 7B2 at the concentration of 10(-7) M. These findings suggest that 7B2 is a secretory protein of rat GH1 cells under certain conditions.
摘要
一种新型垂体蛋白“7B2”由GH1细胞分泌。在人促生长激素释放因子（GRF）存在的情况下，7B2的分泌呈剂量依赖性增加。相比之下，一种生长抑素类似物SMS 201 - 995在浓度为10（-7）M时，对7B2的基础分泌和GRF诱导的分泌均有抑制作用。这些发现表明，7B2在某些条件下是大鼠GH1细胞的一种分泌蛋白。
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