人类多药耐药1基因多态性与特发性肺纤维化
Human Multidrug Resistance 1 gene polymorphisms and Idiopathic Pulmonary Fibrosis.
作者信息
Martinelli Marcella, Scapoli Luca, Pacilli Angela Maria Grazia, Carbonara Paolo, Girardi Ambra, Mattei Gabriella, Rodia Maria Teresa, Solmi Rossella
机构信息
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Bologna, Italy ; Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy.
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Bologna, Italy.
出版信息
J Res Med Sci. 2015 Jan;20(1):93-6.
BACKGROUND
For the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics.
MATERIALS AND METHODS
We genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subjects with Italian origins.
RESULTS
No evidence of association was detected.
CONCLUSION
There are 50 known MDR1 SNPs, and their role is explored in terms of the effectiveness of drug therapy. We consider our small-scale preliminary study as a starting point for further research.
背景
我们首次检测了人类多药耐药基因1（MDR1）多态性（单核苷酸多态性，SNPs）与特发性肺纤维化（IPF）之间的关联。几种MDR1多态性与它们改变药物敏感性和药代动力学的病理状况相关。
材料与方法
我们对48例IPF患者和100名意大利裔对照受试者的三种MDR1多态性进行了基因分型。
结果
未检测到关联证据。
结论
已知有50种MDR1 SNPs，并且就药物治疗的有效性对它们的作用进行了探索。我们将我们的小规模初步研究视为进一步研究的起点。
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