Arioli F, Pasquale E, Panseri S, Bonizzi L, Labella G F, Casati A, Foschini S, Chiesa L
a Department of Health, Animal Science and Food Safety , University of Milan , Milan , Italy.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(6):833-40. doi: 10.1080/19440049.2015.1028482. Epub 2015 Apr 9.
The debate about the origin of prednisolone in animal organisms has lasted for 5 years. Bovine species have been the most studied, but studies on humans and horses are also present in the literature. Even if prednisolone in pigs does not yet represent a problem for control agencies, interest has recently increased with regard to this species. To date, there has been just a single study in the literature about this topic, performed on 10 sows treated with prednisolone or a synthetic analogue of adrenocorticotropic hormone. We therefore initiated a study on 80 pigs, a number considered representative in relation to the expected frequency (prevalence) of prednisolone detection in urine collected at slaughter. Prednisolone was detected in urine both at the farm and at the slaughterhouse, with a concentration and frequency higher at slaughter. The presence of prednisolone was also studied in the adrenal glands, where the corticosteroids are produced in response to stress, and it was detected in 89% of the samples. These results, together with the similar behaviours of prednisolone and cortisol, i.e. a mutual rise in the two corticosteroids in urine collected at the slaughterhouse and the correlation between the concentrations of the two corticosteroids in the adrenal glands, seem to indicate an endogenous origin of prednisolone in pigs.
关于泼尼松龙在动物机体中的来源的争论已经持续了5年。牛类是研究最多的，但文献中也有关于人类和马匹的研究。即使猪体内的泼尼松龙对监管机构来说尚未构成问题，但最近对该物种的关注度有所提高。迄今为止，文献中仅有一项关于此主题的研究，该研究对10头用泼尼松龙或促肾上腺皮质激素合成类似物治疗的母猪进行。因此，我们对80头猪开展了一项研究，就屠宰时收集的尿液中泼尼松龙检测的预期频率（患病率）而言，80头这一数量被认为具有代表性。在农场和屠宰场收集的尿液中均检测到了泼尼松龙，屠宰时其浓度和检出频率更高。我们还对肾上腺进行了研究，肾上腺是在应激反应下产生皮质类固醇的部位，在89%的样本中检测到了泼尼松龙。这些结果，再加上泼尼松龙和皮质醇的相似行为，即在屠宰场收集的尿液中这两种皮质类固醇相互升高，以及肾上腺中这两种皮质类固醇浓度之间的相关性，似乎表明猪体内的泼尼松龙来源于内源性。
