Brănişteanu D D, Brănişteanu D D, Haulică I
Institute of Medicine and Pharmacy, Dept. of Physiology, Iaşi, Romania.
Physiologie. 1989 Oct-Dec;26(4):261-6.
Calmodulin seems to be strongly involved in the process of transmitter release. By activating a specific proteinkinase system, calmodulin could initiate the phosphorylation of some axolemal or vesicular protein, thus triggering the exocytosis of the synaptic vesicles and the transmitter release. Under these conditions it was to be expected that a calmodulin blocking agent such as trifluoperazine, used in appropriate concentrations for this effect, should block the transmitter release. Contradictory results determined us to reexamine the question under extended experimental conditions. Our data suggest that calmodulin could both activate and block the transmitter release through probably different mechanisms.
钙调蛋白似乎在神经递质释放过程中发挥着重要作用。通过激活特定的蛋白激酶系统，钙调蛋白可以引发某些轴膜或囊泡蛋白的磷酸化，从而触发突触囊泡的胞吐作用以及神经递质的释放。在这种情况下，可以预期，使用适当浓度的钙调蛋白阻断剂（如三氟拉嗪）来产生这种效应时，应该会阻断神经递质的释放。相互矛盾的结果促使我们在更广泛的实验条件下重新审视这个问题。我们的数据表明，钙调蛋白可能通过不同的机制既激活又阻断神经递质的释放。
