Feeney Kendra J, Mastrangelo Michael J
Department of Medical Oncology, Sidney Kimmel School of Medicine, Thomas Jefferson University, 1025 Walnut Street, Suite 700, Philadelphia, PA 19107, USA.
Department of Medical Oncology, Sidney Kimmel School of Medicine, Thomas Jefferson University, 1025 Walnut Street, Suite 700, Philadelphia, PA 19107, USA.
Surg Oncol Clin N Am. 2015 Apr;24(2):299-308. doi: 10.1016/j.soc.2014.12.007.
Intratumoral therapy with bacteria/bacterial products dates to at least the 1890s. Over the decades this has expanded beyond the use of microbes and microbial products to include chemicals, cancer chemotherapeutic agents, cytokines, recombinant organisms, and hybrid molecules. The appeal of this method of delivery is the ability to deliver high concentrations of the therapeutic agent directly to the tumor, often with minimal side effects. This article summarizes the use and efficacy of the various agents used in the past and present in the treatment of in-transit and satellite metastases in melanoma.
肿瘤内细菌/细菌产物治疗至少可追溯到19世纪90年代。几十年来，这种治疗方法已从使用微生物和微生物产物扩展到包括化学物质、癌症化疗药物、细胞因子、重组生物体和杂交分子。这种给药方法的吸引力在于能够将高浓度的治疗剂直接递送至肿瘤，且通常副作用最小。本文总结了过去和现在用于治疗黑色素瘤的移行转移和卫星转移的各种药物的使用情况及疗效。
