Gundamaraju Rohit, Singla Rajeev K, Vemuri Ravi Chandra, Sekaran Shamala Devi
SERB-Young Scientist/ Principal Investigator, Division of Biotechnology, NetajiSubhas Institute of Technology, Sector-3, Dwarka, New Delhi-110078, India.
Mini Rev Med Chem. 2015;15(3):211-9. doi: 10.2174/138955751503150312121302.
Entamoeba being an internal parasite is the causative organism of many human and animal infections with lethal consequences. Chemotherapy against Entamoeba was well established by both synthetic and natural products. Vigorous attainments were made by different researchers all over the world for discovering better chemical entities and the potent formulations. Preexisting compounds were developed into non-cytotoxic and with an enhanced therapeutic compounds by usage of multiparametric optimization techniques like QSAR, and molecular docking. The present review is therefore an aerial perspective of importance of medicinal chemistry in anti-amoebic chemotherapy. The review elucidates the existing synthetic compounds, their analogues, natural products, in silico studies and some novel methods adopted for the drug design as anti-amoebic agents which would be of assured benefit in the future drug design.
作为一种体内寄生虫，溶组织内阿米巴是许多导致人类和动物感染并带来致命后果的病原体。针对溶组织内阿米巴的化学疗法已通过合成产品和天然产品得到了充分确立。世界各地的不同研究人员在发现更好的化学实体和高效制剂方面取得了显著成就。通过使用如定量构效关系（QSAR）和分子对接等多参数优化技术，将先前存在的化合物开发成了无细胞毒性且具有增强治疗效果的化合物。因此，本综述是从宏观角度审视药物化学在抗阿米巴化疗中的重要性。该综述阐明了现有的合成化合物、其类似物、天然产物、计算机模拟研究以及为设计抗阿米巴药物所采用的一些新方法，这些方法在未来药物设计中将具有确定的益处。
