Novick Rachel, Anderson Grace, Miller Eric, Allgeier Daniel, Unice Ken
ChemRisk, LLC, San Francisco, CA, USA.
ChemRisk, LLC, Pittsburgh, PA, USA.
Photodermatol Photoimmunol Photomed. 2015 Jul;31(4):212-23. doi: 10.1111/phpp.12171. Epub 2015 Apr 5.
BACKGROUND/PURPOSE: Studies have shown that individuals apply less than the 2 mg/cm(2) lotion sunscreen needed to achieve the labeled SPF. However, there is little information regarding the application of spray and stick sunscreens. The objectives of this study were to measure the amount of sunscreen applied to skin by different application methods, to examine the relationship between application and demographic factors, and to evaluate the potential for sensitization from the preservative methylisothiazolinone (MI) in lotion sunscreens.
Fifty-two participants applied lotion, spray, and stick sunscreen and answered a questionnaire. Lotion sunscreens were tested for MI content, and a margin of safety for the induction of skin sensitization was calculated.
The geometric means for the application thickness of lotion, spray, and stick sunscreens were 1.1, 1.6, and 0.35 mg/cm(2), respectively. Several factors influenced sunscreen application thickness, including age and skin type. The MI concentration in tested sunscreen lotions ranged from <1 to 5.6 ppm, and likely MI exposures were below the threshold for induction of allergy (margin of safety > 8.1).
In this study, sunscreen users applied different amounts of sunscreen depending on the application method, affording different levels of sun protection. Typical use of the sunscreens is not likely to result in MI sensitization.
背景/目的:研究表明,人们涂抹的乳液型防晒霜量低于达到标注防晒系数(SPF)所需的2毫克/平方厘米。然而,关于喷雾型和棒状防晒霜的涂抹情况,相关信息较少。本研究的目的是测量不同涂抹方法涂抹在皮肤上的防晒霜量,研究涂抹量与人口统计学因素之间的关系,并评估乳液型防晒霜中防腐剂甲基异噻唑啉酮(MI)引起皮肤过敏的可能性。
52名参与者涂抹乳液型、喷雾型和棒状防晒霜,并回答一份问卷。检测乳液型防晒霜中的MI含量,并计算皮肤致敏诱导的安全系数。
乳液型、喷雾型和棒状防晒霜涂抹厚度的几何平均值分别为1.1、1.6和0.35毫克/平方厘米。几个因素会影响防晒霜的涂抹厚度,包括年龄和皮肤类型。测试的乳液型防晒霜中MI浓度范围为<1至5.6 ppm,可能的MI暴露低于过敏诱导阈值(安全系数>8.1)。
在本研究中,防晒霜使用者根据涂抹方法涂抹不同量的防晒霜,提供不同程度的防晒保护。防晒霜的典型使用不太可能导致MI致敏。