催产素受体基因多态性（rs53576）与神经性贪食症之间的关联。
Association between the oxytocin receptor gene polymorphism (rs53576) and bulimia nervosa.
作者信息
Kim Youl-Ri, Kim Jeong-Hyun, Kim Chan-Hyung, Shin Jae Gook, Treasure Janet
机构信息
Department of Neuropsychiatry, Seoul Paik Hospital, Inje University College of Medicine, Seoul, South Korea; Institute of Eating Disorders and Mental Health, Inje University, Seoul, South Korea.
出版信息
Eur Eat Disord Rev. 2015 May;23(3):171-8. doi: 10.1002/erv.2354. Epub 2015 Mar 15.
OBJECTIVE
Oxytocin circuits are implicated in the regulation of appetite and weight. Variants in the oxytocin receptor (OXTR) gene have been associated with bulimic behaviour. This study aimed to investigate the association between the OXTR gene and eating disorders.
METHOD
We genotyped six single nucleotide polymorphisms, rs53576, rs237879, rs2228485, rs13316193, rs2254298 and rs1042778, located within the OXTR gene in Korean patients with eating disorders using the single-base extension method. We studied a total of 262 women, including 69 patients with anorexia nervosa, 90 patients with bulimia nervosa (BN), and 103 healthy women.
RESULTS
We found a positive association between the G allele of OXTR rs53576 and BN. In the BN group, the G carriers showed a high score on the behavioural inhibition system.
CONCLUSIONS
These findings suggest the involvement of the oxytocinergic system in the mechanism that underlies BN.
目的
催产素通路与食欲和体重的调节有关。催产素受体（OXTR）基因的变异与暴食行为有关。本研究旨在探讨OXTR基因与饮食失调之间的关联。
方法
我们采用单碱基延伸法，对韩国饮食失调患者OXTR基因内的六个单核苷酸多态性位点rs53576、rs237879、rs2228485、rs13316193、rs2254298和rs1042778进行基因分型。我们共研究了262名女性，其中包括69名神经性厌食症患者、90名神经性贪食症（BN）患者和103名健康女性。
结果
我们发现OXTR rs53576的G等位基因与BN之间存在正相关。在BN组中，G等位基因携带者在行为抑制系统上得分较高。
结论
这些发现表明催产素能系统参与了BN潜在的机制。
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