Lucht Michael J, Barnow Sven, Sonnenfeld Christine, Ulrich Ines, Grabe Hans Joergen, Schroeder Winnie, Völzke Henry, Freyberger Harald J, John Ulrich, Herrmann Falko H, Kroemer Heyo, Rosskopf Dieter
Hospital for Psychiatry and Psychotherapy, University of Greifswald at HELIOS-Hanseklinikum Stralsund, Rostocker Chaussee 70, Stralsund, Germany.
Nord J Psychiatry. 2013 Feb;67(1):15-21. doi: 10.3109/08039488.2012.700731. Epub 2012 Jul 19.
BACKGROUND/AIMS: The application of intranasal oxytocin enhances facial emotion recognition in normal subjects and in subjects with autism spectrum disorders (ASD). In addition, various features of social cognition have been associated with variants of the oxytocin receptor gene (OXTR). Therefore, we tested for associations between mind-reading, a measure for social recognition and OXTR polymorphisms.
76 healthy adolescents and young adults were tested for associations between OXTR rs53576, rs2254298, rs2228485 and mind-reading using the "Reading the Mind in the Eyes Test" (RMET).
After Bonferroni correction for multiple comparisons, rs2228485 was associated with the number of incorrect answers when subjects evaluated male faces (P =0.000639). There were also associations between OXTR rs53576, rs2254298 and rs2228485 and other RMET dimensions according to P <0.05 (uncorrected).
This study adds further evidence to the hypothesis that genetic variations in the OXTR modulate mind-reading and social behaviour.
背景/目的：鼻内注射催产素可增强正常受试者及自闭症谱系障碍（ASD）患者对面部表情的识别能力。此外，社会认知的各种特征已与催产素受体基因（OXTR）的变异相关联。因此，我们测试了心理理论（一种社会认知测量方法）与OXTR多态性之间的关联。
使用“眼睛解读心理测试”（RMET）对76名健康青少年和青年成人进行测试，以检测OXTR rs53576、rs2254298、rs2228485与心理理论之间的关联。
在对多重比较进行Bonferroni校正后，rs2228485与受试者评估男性面孔时的错误答案数量相关（P = 0.000639）。根据P < 0.05（未校正），OXTR rs53576、rs2254298和rs2228485与其他RMET维度之间也存在关联。
本研究进一步证明了OXTR基因变异调节心理理论和社会行为这一假说。
