Lee Mak-Soon, Kim Chong-Tai, Kim In-Hwan, Kim Yangha
a Department of Nutritional Science and Food Management , Ewha Womans University , Seoul , Korea.
Biosci Biotechnol Biochem. 2015;79(5):816-9. doi: 10.1080/09168451.2014.997186. Epub 2015 Mar 16.
In this study, we investigated the effects of Korean red ginseng water extract (KRGE) on hepatic lipid accumulation in HepG2 cells. KRGE decreased hepatic triglyceride and cholesterol levels. Further, KRGE suppressed expression of fatty acid synthase (FAS) and 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase. These results suggest that KRGE may reduce hepatic lipid accumulation by inhibition of FAS and HMG-CoA reductase expression in HepG2 cells.
在本研究中，我们调查了韩国红参水提取物（KRGE）对HepG2细胞肝脂质积累的影响。KRGE降低了肝脏甘油三酯和胆固醇水平。此外，KRGE抑制了脂肪酸合酶（FAS）和3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶的表达。这些结果表明，KRGE可能通过抑制HepG2细胞中FAS和HMG-CoA还原酶的表达来减少肝脏脂质积累。
