Dahiya Kiran, Kulshrestha Manish Raj, Bansal Piyush, Ghalaut Veena Singh, Kulshrestha Rupita, Dahiya Priya, Dhupper Vasudha
Department of Biochemistry and.
Hypertens Pregnancy. 2015 May;34(2):204-8. doi: 10.3109/10641955.2014.1001901. Epub 2015 Mar 16.
Pre-eclampsia is associated with ischemia and increased oxidative stress, which may lead to modification of plasma albumin to ischemia modified albumin (IMA).
IMA levels were estimated in cord blood of 30 newborns born to pre-eclamptic mothers and compared with 30 normal newborns. IMA was estimated colorimetrically and the results were compared statistically.
The levels of IMA were found to be significantly higher (p < 0.001) in newborns born to pre-eclamptic mothers (0.835 ± 0.02 ABSU) as compared to those born to normal mothers (0.325 ± 0.01 ABSU).
IMA may act as a marker of ischemia and oxidative stress in newborns delivered to pre-eclamptic mothers.
子痫前期与局部缺血及氧化应激增加有关，这可能导致血浆白蛋白转变为缺血修饰白蛋白（IMA）。
对30名子痫前期母亲所生新生儿的脐血进行IMA水平评估，并与30名正常新生儿进行比较。采用比色法测定IMA，并对结果进行统计学比较。
发现子痫前期母亲所生新生儿的IMA水平（0.835±0.02ABSU）显著高于正常母亲所生新生儿（0.325±0.01ABSU）（p<0.001）。
IMA可能是子痫前期母亲所生新生儿局部缺血和氧化应激的标志物。
