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[噻加宾——难治性癫痫治疗的个人经验]

[Tiagabine--own experience in the refractory epilepsy treatment].

作者信息

Błaszczyk Barbara

机构信息

Wydział Nauk o Zdrowiu WSEiP, Kielce.

出版信息

Wiad Lek. 2013;66(2 Pt 2):175-9.

Abstract

Tiagabine belongs to a new generation of antiepileptic drugs with a unique mechanism of action. It is well-absorbable from the gastrointestinal tract, has a linear pharmacokinetics, does not affect cognitive function and it interacts poorly with other antiepileptic drugs. Tiagabine is recommended for adults and children past 12 years of age with epilepsy, suffering from partial seizures, with and without secondary generalization. Following the period of a great enthusiasm as to the use of tiagabine, it was put aside, though unfairly, according to the author's own studies as well as the reports in current literature, it still has its place in the treatment of drug-resistant epilepsy.

摘要

噻加宾属于新一代抗癫痫药物,作用机制独特。它可从胃肠道良好吸收,具有线性药代动力学,不影响认知功能,且与其他抗癫痫药物相互作用较弱。噻加宾适用于12岁及以上患有癫痫、伴有或不伴有继发性全身性发作的部分性发作的成人和儿童。在对噻加宾的使用经历了一段极大的热情期之后,它被搁置一旁,尽管根据作者自己的研究以及当前文献中的报道,这种搁置并不公平,但它在耐药性癫痫的治疗中仍占有一席之地。

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