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利用Affymetrix微阵列鉴定人类乳腺细胞中受视黄酸类化合物（LGD1069、LG100268和Ro25-7386）调控的生物标志物。

Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray.

作者信息

Seo Hye-Sook, Woo Jong-Kyu, Shin Yong Cheol, Ko Seong-Gyu

机构信息

Laboratory of Clinical Biology and Pharmacogenomics and Center for Clinical Research and Genomics, College of Korean Medicine, Kyung Hee University, Dongdaemun‑gu, Seoul 130‑701, Republic of Korea.

Laboratory of Preventive Pharmacy, College of Pharmacy, Gachon University of Medicine and Science, Yeonsu‑gu, Incheon 406‑840, Republic of Korea.

出版信息

Mol Med Rep. 2015 Jul;12(1):800-18. doi: 10.3892/mmr.2015.3480. Epub 2015 Mar 12.

DOI:10.3892/mmr.2015.3480
PMID:25778982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4438952/
Abstract

Retinoids possess anti-proliferative properties, which suggests that they possess chemopreventive and therapeutic potential against cancer. In the current study, genes modulated by rexinoids (retinoid X receptor (RXR)-pan agonists, LGD1069 and LG100268; and the RXRα agonist, Ro25-7386) were identified using an Affymetrix microarray in normal and malignant breast cells. It was observed that LGD1069, LG100268 and Ro25-7386 suppressed the growth of breast cells. Secondly, several rexinoid-regulated genes were identified, which are involved in cell death, cell growth/maintenance, signal transduction and response to stimulus. These genes may be associated with the growth-suppressive activity of rexinoids. Therefore, the identified genes may serve as biomarkers and novel molecular targets for the prevention and treatment of breast cancer.

摘要

维甲酸具有抗增殖特性，这表明它们具有针对癌症的化学预防和治疗潜力。在当前研究中，使用Affymetrix微阵列在正常和恶性乳腺细胞中鉴定了由视黄酸X受体（RXR）泛激动剂（LGD1069和LG100268）以及RXRα激动剂Ro25-7386调控的基因。观察到LGD1069、LG100268和Ro25-7386抑制了乳腺细胞的生长。其次，鉴定了几个受视黄酸X受体激动剂调控的基因，这些基因参与细胞死亡、细胞生长/维持、信号转导和对刺激的反应。这些基因可能与视黄酸X受体激动剂的生长抑制活性相关。因此，所鉴定的基因可能作为乳腺癌预防和治疗的生物标志物及新的分子靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/eb222163b9c3/MMR-12-01-0800-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/e4d1adf48c1d/MMR-12-01-0800-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/529f3e52ceee/MMR-12-01-0800-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/02a73f45469a/MMR-12-01-0800-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/119d3fc255ab/MMR-12-01-0800-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/c1c611696381/MMR-12-01-0800-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/0bc22945ca25/MMR-12-01-0800-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/eb222163b9c3/MMR-12-01-0800-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/e4d1adf48c1d/MMR-12-01-0800-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/529f3e52ceee/MMR-12-01-0800-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/02a73f45469a/MMR-12-01-0800-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/119d3fc255ab/MMR-12-01-0800-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/c1c611696381/MMR-12-01-0800-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/0bc22945ca25/MMR-12-01-0800-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ade6/4438952/eb222163b9c3/MMR-12-01-0800-g06.jpg

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