聚偏氟乙烯（PVDF）中空纤维血液透析器的研究。

Research on polyvinylidene fluoride (PVDF) hollow-fiber hemodialyzer.

作者信息

Zhang Qinglei, Lu Xiaolong, Zhao Lihua, Liu Juanjuan, Wu Chunfeng

出版信息

Biomed Tech (Berl). 2016 Jun 1;61(3):309-16. doi: 10.1515/bmt-2014-0190.

DOI:10.1515/bmt-2014-0190

Abstract

In this study, polyvinylidene fluoride (PVDF) hollow-fiber hemodialysis membranes were prepared by non-solvent-induced phase separation. The PVDF hollow-fiber hemodialyzers were prepared by centrifugal casting. The results showed that the PVDF membrane had better mechanical and separation properties when the membrane wall thickness was 40 μm and the N,N-dimethylacetamide in the core was 70 Vol%. Compared with commercial polysulfone hemodialysis membrane (Fresenius F60S membrane), the PVDF membrane had better mechanical property and ultrafiltration (UF) flux of pure water. The PVDF dialyzer's removal efficiency for middle molecules was proven to be much higher than that of the F60S dialyzer. The UF coefficient of a high-flux PVDF dialyzer is 62.6 ml/h/mm Hg, whereas F60S is 42.5 ml/h/mm Hg, which can promote clearance for middle molecules.

摘要

在本研究中，通过非溶剂诱导相分离制备了聚偏氟乙烯（PVDF）中空纤维血液透析膜。采用离心浇铸法制备了PVDF中空纤维血液透析器。结果表明，当膜壁厚为40μm且芯部N，N-二甲基乙酰胺含量为70体积%时，PVDF膜具有更好的力学性能和分离性能。与商用聚砜血液透析膜（费森尤斯F60S膜）相比，PVDF膜具有更好的力学性能和纯水超滤（UF）通量。事实证明，PVDF透析器对中分子的清除效率远高于F60S透析器。高通量PVDF透析器的超滤系数为62.6 ml/h/mm Hg，而F60S为42.5 ml/h/mm Hg，这可以促进对中分子的清除。