[1,4]苯并恶嗪-2,3-二酮作为抗过敏剂。

[1,4]Benzoxazine-2,3-diones as antiallergic agents.

作者信息

Loev B, Jones H, Brown R E, Huang F C, Khandwala A, Leibowitz M J, Sonnino-Goldman P

出版信息

J Med Chem. 1985 Jan;28(1):24-7. doi: 10.1021/jm00379a006.

Abstract

The synthesis of a series of [1,4]benzoxazine-2,3-diones and a new class of compounds, benzobisoxazinetetrones, is described. These compounds were evaluated for their effect in the rat mast cell (RMC) test passively sensitized in vitro with rat antiovalbumin serum and for their effect in inhibitory passive cutaneous anaphylaxis (PCA) in the rat. Some of these compounds are of the same potency level as disodium cromglycate in the RMC test and some are effective orally in PCA.

摘要

本文描述了一系列[1,4]苯并恶嗪-2,3-二酮以及一类新型化合物苯并双恶嗪四酮的合成。对这些化合物在体外经大鼠抗卵清蛋白血清被动致敏的大鼠肥大细胞（RMC）试验中的作用，以及在大鼠抑制性被动皮肤过敏反应（PCA）中的作用进行了评估。其中一些化合物在RMC试验中的效力水平与色甘酸二钠相同，还有一些在PCA中口服有效。