Statz T, Statz A, Felgenhauer K
Dtsch Med Wochenschr. 1985 Jan 11;110(2):55-8. doi: 10.1055/s-2008-1068774.
The levels of the individual proteins albumin, caeruloplasmin, immunoglobulin G, and alpha 2-macroglobulin were determined by Laurell's electroimmunoassay in the serum and urine of 127 children. Their age ranged from 29 gestational weeks to 13 years. Highest levels of the proteins in the urine were found during the first days of life. The values did not depend on gestational age. The urine concentrations are influenced by glomerular filtration and the reabsorption of proteins and water. The steady state of these functions can be characterized by the serum/urine concentration ratios and the clearance of the proteins. In the first days after birth the permeability of the renal barrier is maximal, the concentration ratios are low and increase markedly up to the end of the first three months; after that, they continue to rise only slightly. The clearances of all the examined individual proteins decrease between term and the third month of life, thereafter increasing until late childhood. The selectivity of the glomerular filtration also shows its highest rate of development during the first days after term.
采用劳雷尔电免疫分析法测定了127名儿童血清和尿液中白蛋白、铜蓝蛋白、免疫球蛋白G和α2-巨球蛋白等单个蛋白质的水平。他们的年龄从孕29周到13岁不等。在出生后的头几天，尿液中这些蛋白质的水平最高。这些值与胎龄无关。尿液浓度受肾小球滤过以及蛋白质和水的重吸收影响。这些功能的稳态可以通过血清/尿液浓度比和蛋白质清除率来表征。出生后的头几天，肾屏障的通透性最大，浓度比很低，到出生后前三个月末显著增加；此后，它们仅略有上升。所有检测的单个蛋白质的清除率在足月至出生后第三个月之间下降，此后一直增加直至儿童晚期。肾小球滤过的选择性在足月后的头几天也显示出最高的发育速率。
