Mansouri Kaweh, Weinreb Robert N
aGlaucoma Sector, Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland bDepartment of Ophthalmology, University of Colorado School of Medicine, Denver, Colorado cHamilton Glaucoma Center and Shiley Eye Institute, University of California San Diego, California, USA.
Curr Opin Ophthalmol. 2015 May;26(3):214-20. doi: 10.1097/ICU.0000000000000144.
To review current status and future of ambulatory 24-h intraocular pressure monitoring. Despite important advances in the diagnosis and management of glaucoma during the last decade, the fundamental understanding of intraocular pressure, its only modifiable risk factor, remains elusive. The current practice of single intraocular pressure measurements during a clinic visit does not adequately reflect the variability of intraocular pressure throughout the 24-h day.
There has been considerable progress recently with the prototype and commercial introduction of continuous 24-h intraocular pressure monitoring devices. Implantable intraocular pressure sensors have the advantage to directly measure intraocular pressure over many months and years, whereas temporary (contact lens based) approaches provide a noninvasive alternative for repeated 24-h periods. This review provides an overview of implantable devices as well as a critical assessment of a 24-h contact lens sensor.
Recent advances in microelectromechanical systems and nanoelectromechanical systems have enabled the development of 24-h intraocular pressure monitoring devices. Once these technologies have shown their safety and efficacy, larger questions as to the data interpretation and handling will arise. It is likely that the use of 24-h intraocular pressure monitoring will herald fundamental changes in our understanding and management of glaucoma.
回顾动态24小时眼压监测的现状与未来。尽管在过去十年中青光眼的诊断和治疗取得了重要进展，但对于眼压这一唯一可改变的危险因素的基本认识仍不明确。目前在门诊就诊时单次测量眼压的做法并不能充分反映24小时内眼压的变化情况。
最近，随着连续24小时眼压监测设备的原型和商业化推出，取得了相当大的进展。可植入眼压传感器具有在数月甚至数年时间内直接测量眼压的优势，而临时（基于隐形眼镜）方法则为重复的24小时时段提供了一种非侵入性的替代方案。本综述概述了可植入设备，并对一种24小时隐形眼镜传感器进行了批判性评估。
微机电系统和纳米机电系统的最新进展推动了24小时眼压监测设备的开发。一旦这些技术证明了其安全性和有效性，关于数据解释和处理的更大问题将会出现。24小时眼压监测的应用很可能会给我们对青光眼的理解和管理带来根本性的变化。
