双层膜的有序性和流动性对去污剂诱导的脂质体融合的影响。
The effect of bilayer order and fluidity on detergent-induced liposome fusion.
作者信息
Saez R, Goñi F M, Alonso A
出版信息
FEBS Lett. 1985 Jan 7;179(2):311-5. doi: 10.1016/0014-5793(85)80541-x.
PMID:2578413
Abstract
Surfactants induce fusion (or increase in size) of sonicated liposomes. This phenomenon is enhanced by cholesterol and inhibited by the intrinsic polypeptide gramicidin A. By comparison with previous physical studies we conclude that liposome 'fusion' is facilitated when both fluidity and static order of the bilayer are high.
摘要
表面活性剂可诱导超声处理过的脂质体融合（或增大尺寸）。胆固醇可增强这一现象，而内在多肽短杆菌肽A则会抑制该现象。通过与之前的物理研究相比较，我们得出结论：当双层膜的流动性和静态有序性都较高时，脂质体的“融合”会更容易发生。
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