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使用失活自体骨与带血管腓骨复合移植对下肢恶性骨肿瘤广泛切除术后进行节段性重建。

Intercalary reconstruction after wide resection of malignant bone tumors of the lower extremity using a composite graft with a devitalized autograft and a vascularized fibula.

作者信息

Ogura Koichi, Miyamoto Shimpei, Sakuraba Minoru, Fujiwara Tomohiro, Chuman Hirokazu, Kawai Akira

机构信息

Department of Musculoskeletal Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

Department of Plastic and Reconstruction Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

出版信息

Sarcoma. 2015;2015:861575. doi: 10.1155/2015/861575. Epub 2015 Feb 16.

Abstract

Introduction. Although several intercalary reconstructions after resection of a lower extremity malignant bone tumor are reported, there are no optimal methods which can provide a long-term reconstruction with fewest complications. We present the outcome of reconstruction using a devitalized autograft and a vascularized fibula graft composite. Materials and Methods. We conducted a retrospective review of 11 patients (7 males, 4 females; median age 27 years) undergoing reconstruction using a devitalized autograft (pasteurization (n = 6), deep freezing (n = 5)) and a vascularized fibula graft composite for lower extremity malignant bone tumors (femur (n = 10), tibia (n = 1)). Results. The mean period required for callus formation and bone union was 4.4 months and 9.9 months, respectively. Four postoperative complications occurred in 3 patients: 2 infections (1 pasteurized autograft, 1 frozen autograft) and 1 fracture and 1 implant failure (both in pasteurized autografts). Graft removal was required in 2 patients with infections. The mean MSTS score was 81% at last follow-up. Conclusions. Although some complications were noted in early cases involving a pasteurized autograft, our novel method involving a combination of a frozen autograft with a vascularized fibula graft and rigid fixation with a locking plate may offer better outcomes than previously reported allografts or devitalized autografts.

摘要

引言。尽管有报道称在下肢恶性骨肿瘤切除术后进行了几种节段性重建,但尚无能够以最少并发症提供长期重建的最佳方法。我们展示了使用失活自体骨移植和带血管腓骨移植复合物进行重建的结果。材料与方法。我们对11例患者(7例男性,4例女性;中位年龄27岁)进行了回顾性研究,这些患者接受了使用失活自体骨移植(巴氏消毒法(n = 6),深度冷冻法(n = 5))和带血管腓骨移植复合物对下肢恶性骨肿瘤(股骨(n = 10),胫骨(n = 1))进行重建。结果。骨痂形成和骨愈合所需的平均时间分别为4.4个月和9.9个月。3例患者出现4例术后并发症:2例感染(1例巴氏消毒自体骨,1例冷冻自体骨),1例骨折和1例植入物失败(均发生在巴氏消毒自体骨中)。2例感染患者需要取出移植物。最后一次随访时平均MSTS评分为81%。结论。尽管在早期涉及巴氏消毒自体骨的病例中发现了一些并发症,但我们采用冷冻自体骨与带血管腓骨移植相结合并使用锁定钢板进行坚强固定的新方法可能比先前报道的同种异体骨或失活自体骨移植提供更好的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a62a/4345269/f0d08832144b/SARCOMA2015-861575.004.jpg

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